SAME 400mg 20 Tablets

(hover to enlarge)


SAME 400mg 20 Tablets

by Life Extension

  • • 20 servings
Retail $28.00Regular $21.42$21.00

Subscribe & Save!

Ships Free (details) with delivery every

Save 25% off retail

Usually Ships in 1-2 Business Days


SAMe (S-adenosyl-methionine) is an amino acid derivative normally synthesized in the body. SAMe is used by the body in three important pathways:

Methylation (contributing methyl groups to activate certain molecules)

The synthesis of polyamines (for cell growth, gene expression, neuronal regeneration, etc. )

Trans-sulfuration (synthesis of cysteine, glutathione, and other sulfate chemicals)

In young, healthy people SAMe is well distributed throughout the body as a result of its synthesis from methionine by enzymes using ATP. However, in sickness and in age, system levels may become depleted. Supplementation of the co-factors folate, TMG, vitamins B6 and B12, together with SAMe appears to be an effective method to overcome this deficiency. There is evidence that SAMe helps to synthesize phosphatidylcholine, which keeps cell membranes fluid and is used in the brain to make the neurotransmitter acetylcholine.

SAMe has multi-modal mechanisms of action that are used throughout the body, and especially the liver. In order to perform its detoxification role, the liver performs large numbers of complex enzymatic reactions continually.

SAMe facilitates healthy methylation enzymatic processes and boosts hepatic levels of the critical antioxidant, glutathione. When liver function is compromised, glutathione is depleted, which leads to free radical damage. In addition, SAMe acts as a methyl donor in the synthesis and formation of phosphatidylcholine and L-cysteine, both necessary for maintaining liver health.

Serving Size

1 tablet, 20 servings per container


Contains soybeans. Contains yeast

Other Ingredients

cellulose, mannitol, methylcellulose phthalate, citric acid, sodium starch glycolate, glyceryl triacetate, croscarmellose sodium, stearic acid, silica, titanium dioxide, yellow ochre.

Suggested Use

Take one tablet two to three times daily in divided doses morning, midday, and late afternoon, or as recommended by a healthcare practitioner. Take with co-factors vitamins B12, B6, and folic acid. * Taking this product with food may avoid gastrointestinal disturbance. Refrigeration is recommended.

Does Not Contain

This product contains no milk, egg, fish, crustacean shellfish, tree nuts, wheat, peanuts, gluten, corn, or rice. Contains no sugar, and no artificial sweeteners, colors, flavors, or preservatives.


SAMe should not be taken by those diagnosed with bipolar disorder.

Supplement Facts

Serving Size is 1 tablet
Amount Per Serving%DV
*Daily Value (DV) not established.

Customers who bought this item also bought

Bilberry Complex Futurebiotics
Bilberry Complex 60 Capsules $6.87
Silymarin Plus™ Source Naturals
Silymarin Plus™ 30 Tablets $4.35

Write a Review

Have you tried Life Extension SAME 400mg? Share your experience with others; Review this product here!