Parthenolide is an active principle of feverfew. It is a sesquiterpene lactone. Parthenolide has anti-inflammatory, antisecretory and spasmolytic activity. It Inhibits the release of various mediators. It inhibits activation of MAP kinase. Parthenolide is often used for migraines and headaches.

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Cautions Parthenoilde may cause an allergic reaction.